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A | BEIRUT -- Lebanon’s militant Hezbollah group said Monday it has started destroying surveillance cameras on several Israeli army posts along the border as tension rose following the Israel-Hamas war that began Oct.7.Hezbollah’s military media arm released a video showing snipers shooting at and destroying surveillance cameras placed on five points along the Lebanon-Israel border including one outside the Israeli town of Metula.The militant group appears to want to prevent the Israeli army from monitoring movements on the Lebanese side of the border after days of fire exchange that left at least seven people dead, including four Hezbollah fighters, on the Lebanese side.Since the Oct. 7, attack by the Palestinian militant Hamas group on southern Israel that killed more than 1,400 Israeli civilians and troops, tension has been on the rise along the Lebanon-Israel border. Hezbollah fighters fired anti-tank missiles on Israeli army positions and Israeli troops shelled border areas on the Lebanese side of the border.Israel and Hezbollah are bitter enemies that fought a monthlong war in the summer of 2006 that ended in a draw. Israel considers the Iran-backed Shiite militant group its most serious immediate threat, estimating that Hezbollah has some 150,000 rockets and missiles aimed at Israel.There are concerns that the powerful Iran-backed Hezbollah could join the war with Israel and earlier this month, President Joe Biden warned other players in the Middle East not to join the conflict and has sent American warships to the region and vowed full support for Israel.Hezbollah legislator Hassan Fadlallah said Sunday that the group is ready for all possibilities adding, “we don’t want to reveal what the next step is.” He said Hezbollah’s next step “is tied to what is going on in Gaza.”French Foreign Minister Catherine Colonna arrived in Beirut where she will meet officials to discuss border tensions.Lebanon’s caretaker Prime Minister Najib Mikati said the country’s politically-paralyzed government has been scrambling to ease tensions along its southern border with Israel and avoid dragging the tiny country into a new war.Earlier Monday, the Israeli military ordered people living in 28 communities near the Lebanese border to evacuate. The military order affects communities that are within 2 kilometers (1.2 miles) of the border.Hezbollah has said the increased strikes were a warning and don't mean the group has decided to go to war.The World Health Organization said Monday it has sent two shipments of medical supplies to Beirut in preparation for potential escalation along the Lebanon-Israel border.。 研究人员利用人工智能解码基因激活中的关键DNA序列。图片来源:美国加州大学圣迭戈分校官网 美国加州大学圣迭戈分校研究人员利用高通量DNA测序和人工智能技术,解码了人类基因中一段名为“起始子”的关键DNA序列特征。这项成果为解析基因表达调控规律和预测DNA突变影响提供了新工具。相关论文发表于最新一期《基因与发育》杂志。 人体不同类型的细胞虽然拥有基本相同的DNA,但由于被激活的基因不同,最终能够形成不同的细胞类型,并执行各自特定的功能。

B | DNA中的一些特殊片段负责精细调控基因表达,使细胞产生酶、激素、蛋白质以及维持细胞结构和功能所需的其他重要成分。如果这些基因没有被正确激活,细胞可能无法正常发挥功能,并可能引发包括癌症在内的多种疾病。 为了进一步弄清DNA中哪些序列负责启动基因表达,研究人员将目光投向了“起始子”。这是基因表达过程中的一个重要DNA区域,是基因编码的信息开始被表达,进而产生具有功能产物的关键区域。

C | 研究人员利用高通量DNA测序技术,检测了约50万个不同“起始子”序列的基因表达活性。随后,他们将这些实验数据用于训练机器学习模型,使AI能够识别“起始子”特有的DNA序列模式。 利用训练出的模型,研究人员进一步在人体基因中搜索“起始子”的特征序列,发现约60%的人类基因含有“起始子”。

D | 他们表示,这些AI模型首次能够预测人类基因中是否存在“起始子”,并解码其DNA碱基序列模式。

E | 相关数据和模型还可用于预测“起始子”相关DNA突变的影响,以及设计具有特定功能的合成启动子,即能够调控基因开启和关闭的DNA序列。 研究人员表示,人类每个细胞中都包含约60亿个DNA碱基,其中蕴含着决定基因何时、何地,以及以多大程度表达的复杂“密码”。此次建立的“起始子”AI模型只是解析这一基因表达“密码”的一小部分,希望未来进一步扩大模型范围,以更加全面地解析人类基因表达调控规律。(记者张佳欣)。
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